David M Knipe Selected Research

Viral DNA

1/2021	ATRX limits the accessibility of histone H3-occupied HSV genomes during lytic infection.
12/2019	Herpes Simplex Virus 1 Lytic Infection Blocks MicroRNA (miRNA) Biogenesis at the Stage of Nuclear Export of Pre-miRNAs.
1/2019	Role for a Filamentous Nuclear Assembly of IFI16, DNA, and Host Factors in Restriction of Herpesviral Infection.
11/2018	ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress.
1/2018	Mechanisms of Host IFI16, PML, and Daxx Protein Restriction of Herpes Simplex Virus 1 Replication.
5/2015	Nuclear sensing of viral DNA, epigenetic regulation of herpes simplex virus infection, and innate immunity.
1/2014	Cellular sensing of viral DNA and viral evasion mechanisms.
1/2013	Kinetics of facultative heterochromatin and polycomb group protein association with the herpes simplex viral genome during establishment of latent infection.
10/2012	Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein.
2/2012	Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis.

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David M Knipe Research Topics

Disease

64	Infections 01/2021 - 03/2002
18	Virus Diseases (Viral Diseases) 01/2021 - 08/2004
13	Latent Infection 12/2019 - 03/2002
10	Herpes Simplex 01/2018 - 01/2005
9	Herpes Genitalis (Genital Herpes) 01/2018 - 01/2005
4	Inflammation (Inflammations) 01/2021 - 01/2005
3	Leukemia 01/2021 - 01/2018
3	Melanoma (Melanoma, Malignant) 01/2020 - 10/2015
3	Neoplasms (Cancer) 01/2020 - 01/2016
2	DNA Virus Infections 01/2022 - 01/2018
2	Osteosarcoma (Osteogenic Sarcoma) 02/2014 - 02/2010
2	Encephalitis (Encephalitis, Rasmussen) 02/2012 - 02/2004
2	Acquired Immunodeficiency Syndrome (AIDS) 05/2011 - 01/2007
1	Vesicular Stomatitis 01/2021
1	Human Influenza (Influenza) 01/2021
1	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2021
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020
1	Superinfection 01/2020
1	Viremia 10/2019
1	HIV Infections (HIV Infection) 01/2018
1	Porcine Reproductive and Respiratory Syndrome (PRRS) 12/2017
1	Paramyxoviridae Infections (Parainfluenza) 04/2015
1	Asymptomatic Infections 12/2014
1	Bites and Stings (Sting) 08/2014
1	Communicable Diseases (Infectious Diseases) 04/2012
1	Central Nervous System Infections (Central Nervous System Infection) 02/2012
1	Herpesviridae Infections (Herpesvirus Infection) 02/2012

Drug/Important Bio-Agent (IBA)

24	Proteins (Proteins, Gene)FDA Link 01/2021 - 05/2003
21	VaccinesIBA 01/2021 - 03/2002
15	ChromatinIBA 01/2021 - 10/2005
12	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 09/2004
12	Viral DNAIBA 01/2021 - 09/2005
10	Antiviral Agents (Antivirals)IBA 01/2021 - 03/2002
10	HeterochromatinIBA 01/2021 - 11/2005
9	InterferonsIBA 01/2021 - 01/2006
8	Histones (Histone)IBA 01/2021 - 11/2005
7	Glycoproteins (Glycoprotein)IBA 01/2021 - 01/2005
7	Viral ProteinsIBA 12/2019 - 03/2002
7	Toll-Like Receptors (Toll-Like Receptor)IBA 02/2012 - 09/2004
5	CytokinesIBA 01/2021 - 09/2004
5	Interferon Type IIBA 12/2017 - 05/2008
4	AntibodiesIBA 01/2021 - 01/2016
4	MicroRNAs (MicroRNA)IBA 12/2019 - 05/2010
3	RNA (Ribonucleic Acid)IBA 01/2022 - 04/2012
3	AntigensIBA 01/2021 - 09/2004
3	Neutralizing AntibodiesIBA 01/2021 - 10/2009
3	Messenger RNA (mRNA)IBA 11/2018 - 04/2008
3	Lysine (L-Lysine)FDA Link 05/2015 - 01/2013
3	Etoposide (VP 16)FDA LinkGeneric 02/2014 - 04/2008
2	Phosphotransferases (Kinase)IBA 01/2022 - 12/2017
2	Nucleosomes (Nucleosome)IBA 01/2021 - 01/2016
2	Peptides (Polypeptides)IBA 01/2020 - 01/2016
2	EnzymesIBA 05/2015 - 12/2014
2	NF-kappa B (NF-kB)IBA 09/2010 - 08/2008
2	monophosphoryl lipid AIBA 10/2009 - 01/2005
2	aluminum sulfate (alum)IBA 10/2009 - 01/2005
2	Complement System Proteins (Complement)IBA 12/2008 - 11/2003
2	Lamin Type A (Lamin A)IBA 05/2008 - 10/2005
2	Green Fluorescent ProteinsIBA 09/2007 - 10/2005
2	ChemokinesIBA 01/2005 - 09/2004
1	Hemagglutinins (Hemagglutinin)IBA 01/2021
1	Influenza Vaccines (Influenza Vaccine)FDA Link 01/2021
1	Promyelocytic Leukemia ProteinIBA 01/2021
1	AutoantigensIBA 01/2020
1	Dactinomycin (Actinomycin)FDA LinkGeneric 12/2019
1	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 10/2019
1	gag Gene Products (gag Protein)IBA 10/2019
1	Neoplasm Antigens (Tumor Antigens)IBA 01/2019
1	MART-1 AntigenIBA 01/2019
1	CCCTC-Binding FactorIBA 01/2018
1	Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)IBA 12/2017
1	Pattern Recognition ReceptorsIBA 12/2017
1	Herpes Simplex Virus VaccinesIBA 01/2016
1	Viral VaccinesIBA 01/2016
1	Long-Acting Thyroid Stimulator (LATS)IBA 01/2016
1	MethyltransferasesIBA 05/2015
1	GlycosaminoglycansIBA 04/2015
1	Heparin (Liquaemin)FDA LinkGeneric 04/2015
1	Heparitin Sulfate (Heparan Sulfate)IBA 04/2015
1	Liposomes (Liposome)IBA 04/2015
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2015
1	Tranylcypromine (Parnate)FDA LinkGeneric 12/2014
1	Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA 12/2014
1	Histone DemethylasesIBA 12/2014
1	Interferon Regulatory FactorsIBA 08/2014
1	HIV Integrase InhibitorsIBA 07/2014
1	Polycomb-Group ProteinsIBA 01/2013
1	SolutionsIBA 01/2013
1	N,N-dodecyl,methyl-polyethylenimineIBA 01/2013
1	SuspensionsIBA 01/2013
1	Anti-Bacterial Agents (Antibiotics)IBA 04/2012
1	Pharmaceutical PreparationsIBA 04/2012
1	LuciferasesIBA 09/2010
1	Complement Receptors (Complement Receptor)IBA 12/2008
1	LaminsIBA 05/2008
1	EuchromatinIBA 03/2008
1	Ouabain (G Strophanthin)IBA 09/2007
1	Transcription Factors (Transcription Factor)IBA 04/2007

Therapy/Procedure

7	Therapeutics 01/2021 - 03/2008
1	Condoms (Condom) 01/2013